# Saved by My Specs: Incidental central retinal vein occlusion uncovering infective endocarditis – A case report

**Authors:** Daniel Broderick, Ciara Murray, Padraig McGettrick, James Woo, Emer Kilbride, James McCarthy, Yvonne O’Meara, Varisha Shahzad, Carlos Mejia-Chew

PMC · DOI: 10.1016/j.idcr.2025.e02484 · IDCases · 2025-12-26

## TL;DR

A 74-year-old man with a prosthetic aortic valve was diagnosed with infective endocarditis after an incidental eye condition revealed during a routine visit.

## Contribution

Highlights the importance of incidental findings in diagnosing complex infective endocarditis cases.

## Key findings

- Central retinal vein occlusion led to the diagnosis of Granulicatella adiacens infective endocarditis.
- Patient required multidisciplinary care due to complications like DRESS syndrome and thrombocytopenia.
- Successful treatment included a 9-week antibiotic course and redo aortic valve replacement.

## Abstract

We describe a case of a 74-year-old man with a history of bioprosthetic aortic valve replacement who was diagnosed with Granulicatella adiacens (G. adiacens) infective endocarditis (IE) following an incidental finding of central retinal vein occlusion (CRVO) during a routine optician visit. Despite minimal symptoms on presentation, blood cultures grew G. adiacens, and imaging revealed a 1 × 1.2 cm aortic valve vegetation plus splenic and cerebral embolic complications. Management was complicated by drug-induced drug rash with eosinophilia and systemic symptoms (DRESS) syndrome, microangiopathic thrombocytopenia, anaemia, and possible subacute glomerulonephritis, leading to deferral of surgery until haematological parameters improved. Following a 9-week antibiotic course and stabilisation of platelet counts, he underwent a successful redo aortic valve replacement, highlighting the indolent yet clinically significant nature of G. adiacens IE and the importance of thorough, multidisciplinary care in complex prosthetic valve infections.

## Linked entities

- **Diseases:** infective endocarditis (MONDO:0000565), DRESS syndrome (MONDO:0015340), thrombocytopenia (MONDO:0002049), glomerulonephritis (MONDO:0002462)

## Full-text entities

- **Diseases:** drug rash (MESH:D005076), valve infections (MESH:D007239), aortic valve vegetation (MESH:D001024), anaemia (MESH:D000743), splenic and cerebral embolic complications (MESH:D020766), CRVO (MESH:D012170), eosinophilia and systemic symptoms (DRESS) syndrome (MESH:D063926), glomerulonephritis (MESH:D005921), G. adiacens IE (MESH:D004696)
- **Species:** Granulicatella adiacens (species) [taxon 46124]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12830133/full.md

## References

12 references — full list in the complete paper: https://tomesphere.com/paper/PMC12830133/full.md

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Source: https://tomesphere.com/paper/PMC12830133