# Markers of immune dysregulation in pediatric patients with severe bronchiolitis

## TL;DR

This study finds immune system differences in children with severe bronchiolitis compared to healthy controls.

## Contribution

The paper identifies specific immune cell and cytokine markers linked to severe bronchiolitis in children.

## Key findings

- Hospitalized patients show significant differences in plasmacytoid dendritic cells and eosinophils.
- Cytokines related to airway inflammation are altered in severe bronchiolitis cases.

## Abstract

Children with bronchiolitis exhibit a unique immunophenotype. We identify a significant difference in plasmacytoid dendritic cells and eosinophils in hospitalized patients as compared to controls, as well as cytokines involved in airway inflammation that are significantly different in hospitalized patients as compared to controls.