# Brachytherapy stents versus conventional plastic stents for the treatment of malignant ureteral obstruction: initial experience

## TL;DR

A new stent with radioactive seeds was tested for treating blocked ureters in cancer patients and showed better outcomes than traditional stents.

## Contribution

A novel brachytherapy stent was developed and evaluated for treating malignant ureteral obstruction.

## Key findings

- The brachytherapy stent showed significantly higher disease response and hematuria control rates.
- Patients with brachytherapy stents had significantly longer overall survival compared to conventional stents.

## Abstract

To evaluate the feasibility of a newly designed integrated plastic stent loaded with radioactive 125I seeds (brachytherapy stent) for the treatment of malignant ureteral obstruction (MUO).

From May 2018 to May 2023, 30 patients with MUO underwent brachytherapy plastic stent placement (experimental group), while 41 patients underwent conventional plastic stent placement (control group). The primary endpoints were technical success, complications, the local disease response rate (DRR) and the gross haematuria control (GHC) rate; the secondary endpoints were the hydronephrosis Girignon score (HGC) and overall survival (OS).

The rates of technical success (100% vs. 100%), complications (26.7% vs. 14.6%) and HGC (1.5 ± 0.5) vs. (1.5 ± 0.5) in the experimental and control groups were not significantly different (p>0.05). The DRR (93.3% vs. 9.8%) and GHC rates (84.2% vs. 20.8%) of the experimental and control groups at 8 weeks were statistically significant (P<0.05). The OS [28.4 month (95% CI: 24.6–32.3) vs. 19.5 month (95% CI: 17.0–22.0)] of the experimental and control groups was significantly different (P<0.05).

This novel brachytherapy stent is safe and effective for the treatment of MUO, but long term follow up is needed.