# Concurrent Scrub Typhus, Dengue, and Leptospirosis: A Rare Triple Co‐Infection: A Case Report and Comprehensive Literature Review

**Authors:** Sulav Kumar Jha, Bistrit Dahal, Anamika Adhikari, Kushal Singh Basnet, Shivaditya Singh, Manaswi Acharya

PMC · DOI: 10.1002/ccr3.71933 · 2026-01-23

## TL;DR

This paper reports a rare case of triple co-infection with scrub typhus, dengue, and leptospirosis, emphasizing the importance of early detection in endemic areas.

## Contribution

The novelty lies in documenting a rare triple co-infection case and highlighting diagnostic challenges in febrile illnesses.

## Key findings

- Triple co-infection with scrub typhus, dengue, and leptospirosis is extremely rare.
- Delayed diagnosis can lead to multi-organ dysfunction and increased mortality.
- High clinical suspicion is essential for timely treatment in endemic regions.

## Abstract

In endemic areas, acute undifferentiated febrile illness has a wide differential with overlapping features that can lead to misdiagnosis. Although triple co‐infection with scrub typhus, dengue, and leptospirosis is extremely rare, high clinical suspicion and early detection are vital to avoid delayed treatment, multi‐organ dysfunction, and mortality.

## Linked entities

- **Diseases:** scrub typhus (MONDO:0019365), dengue (MONDO:0005502), leptospirosis (MONDO:0005825)

## Full-text entities

- **Diseases:** Scrub Typhus (MESH:D012612), undifferentiated febrile illness (MESH:C580334), Leptospirosis (MESH:D007922), multi-organ dysfunction (MESH:D009102), Dengue (MESH:D003715), Co-Infection (MESH:D060085)

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12828272/full.md

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Source: https://tomesphere.com/paper/PMC12828272