Peptides in wound healing: A comprehensive review of their roles, challenges, and hydrogel-based delivery systems
Rafl M. Kamil, Shaik Nyamathulla, Syed Mahmood
TL;DR
This review explores how peptides and hydrogel-based delivery systems can improve wound healing, especially for chronic wounds.
Contribution
The paper provides a comprehensive overview of peptides' roles and hydrogel-based delivery systems in wound healing.
Findings
Peptides have antimicrobial, anti-inflammatory, and pro-regenerative properties that aid wound healing.
Hydrogels offer effective delivery systems for peptides in chronic wound treatment.
Peptides from natural and synthetic sources are being explored for clinical applications.
Abstract
Chronic wounds are characterized by prolonged healing durations and disrupted progression through the normal phases of wound healing, hemostasis, inflammation, proliferation, re-epithelialization and remodeling. These wounds are often complicated by persistent infections and underlying conditions like diabetic mellitus, which hinders effective tissue regeneration. Traditional dressings provide limited therapeutic benefits; therefore, recent advancements in wound care have introduced peptide-based therapies that have gained considerable attention for their multifunctional roles in modulating wound repair. Peptides possess intrinsic antimicrobial, anti-inflammatory, angiogenic, and pro-regenerative properties, enabling them to regulate diverse cellular and molecular events across all stages of healing. This review highlights the mechanistic roles of therapeutic peptides in regulating and…
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
Click any figure to enlarge with its caption.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
Figure 9
Figure 10
Figure 11Peer Reviews
No public reviews on file for this paper yet. If you reviewed it on a platform where reviews are public (OpenReview, ICLR, NeurIPS, ICML), you can paste yours below so the community can read it here.
Videos
No videos yet. Explain this paper in a talk, walkthrough, or lecture? Add one.
Taxonomy
TopicsWound Healing and Treatments · Antimicrobial Peptides and Activities · Biochemical and Structural Characterization