Biological age acceleration associates with Alzheimer's disease plasma biomarker levels
Jaclyn M. Eissman, Yiyi Ma, Min Qiao, Dolly Reyes‐Dumeyer, Angel Piriz, Annie J. Lee, Rafael A. Lantigua, Martin Medrano, Diones Rivera Mejia, Lawrence S. Honig, Francine Grodstein, David A. Bennett, Philip L. De Jager, Clifton L. Dalgard, Richard Mayeux, Badri N. Vardarajan
TL;DR
This study finds that biological age, measured through blood methylation, is linked to Alzheimer's disease biomarkers in a Hispanic population.
Contribution
The study shows biological age acceleration is associated with plasma AD biomarkers in a non-European cohort.
Findings
Age acceleration was significantly associated with P-tau217 and other plasma biomarkers.
Biomarker associations were stronger in APOE-ε4 non-carriers.
CD4 and CD8 T-cell methylation levels correlate with age acceleration.
Abstract
Epigenetic clocks associate with neuropathology and Alzheimer's disease (AD) clinical risk, but findings are mixed regarding whether clocks associate with blood‐based biomarkers and in non‐European populations. We calculated biological age and age acceleration from blood methylation data in 704 older Hispanic adults and tested associations with clinical diagnosis and antemortem biomarker levels. Age acceleration was significantly associated with sex, clinical diagnosis, and levels of eight plasma biomarkers, including P‐tau217 levels. Additionally, biomarker associations trended more significantly among APOE‐ε4 non‐carriers. We also identified that methylation levels in CD4 and CD8 T‐cell types are associated with age acceleration. We demonstrated that biological age acceleration, measured in blood, in a Hispanic cohort enriched for preclinical individuals, can stratify clinical AD…
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Taxonomy
TopicsEpigenetics and DNA Methylation · Gut microbiota and health · Alzheimer's disease research and treatments