# P2X4 receptors as the dynamic regulators of auditory sensory cell activity: a potential new mechanism for protecting hearing?

**Authors:** Alizée Fisher-Ridoux, Haruna Suzuki-Kerr

PMC · DOI: 10.1007/s11302-026-10130-0 · 2026-01-22

## Full-text entities

- **Genes:** Syn1 (synapsin I) [NCBI Gene 20964] {aka Syn-1, Syn1-S}, Chat (choline O-acetyltransferase) [NCBI Gene 12647] {aka B230380D24Rik, CHOACTase}, P2rx2 (purinergic receptor P2X, ligand-gated ion channel, 2) [NCBI Gene 231602] {aka P2X2a, P2x2}, Myo15a (myosin XVA) [NCBI Gene 17910] {aka Myo15, sh-2, sh2}
- **Diseases:** autosomal dominant non-syndromic deafness (OMIM:600652), acoustic trauma (MESH:D006317), drop (MESH:D020427), hypersensitivity (MESH:D004342), sensorineural hearing loss (MESH:D006319), cochlear damage (MESH:D015834), hearing loss (MESH:D034381)
- **Chemicals:** ATP (MESH:D000255), acetylcholine (MESH:D000109), Ca2+ (-)
- **Species:** Sus scrofa (pig, species) [taxon 9823], Mus musculus (house mouse, species) [taxon 10090], Callithrix jacchus (common marmoset, species) [taxon 9483], Rattus norvegicus (brown rat, species) [taxon 10116], Ovis aries (domestic sheep, species) [taxon 9940], Homo sapiens (human, species) [taxon 9606]
- **Cell lines:** C57BL/6J — Mus musculus (Mouse), Transformed cell line (CVCL_C0MW)

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Source: https://tomesphere.com/paper/PMC12827844