Modeling the pre-metastatic niche of gastric cancer peritoneal metastasis under spatiotemporal resolution and investigating EVs-mediated immune suppression

TL;DR

This review explores how gastric cancer spreads to the peritoneum by studying pre-metastatic niches and the role of extracellular vesicles in suppressing the immune system.

Contribution

The paper introduces a novel approach using organoid models with high spatiotemporal resolution to study pre-metastatic niche dynamics in gastric cancer.

Findings

Organoid models combined with high-resolution imaging reveal dynamic changes in the pre-metastatic niche.

Extracellular vesicles play a key role in immune suppression during gastric cancer metastasis.

The review identifies current challenges and potential therapeutic targets for treating gastric cancer peritoneal metastasis.

Abstract

Gastric cancer peritoneal metastasis (GCPM) is the leading cause of death in patients with advanced gastric cancer. The presence of ascites creates favorable conditions for the formation of the pre-metastatic niche (PMN), thereby providing a conducive environment for cancer cell metastasis. However, the mechanisms behind the formation of the pre-metastatic niche (PMN) are still not fully understood. This review examines the dynamic changes in the PMN of gastric cancer using organoid models combined with high spatiotemporal resolution and looks into the role of extracellular vesicles (EVs) in mediating immune suppression. It gives an overview of the latest advances in organoid modeling technologies, clarifies the biological characteristics of EVs, and discusses their functions in immune regulation. Furthermore, this review also highlights current challenges in this field, proposes future research directions, and identifies potential therapeutic targets. Bringing these insights together is intended to deepen understanding of gastric cancer metastasis and support the development of more effective therapeutic strategies.

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