Genetic landscape of Italian SRLV: insights from passive surveillance-based phylogenetic analysis
Paola Gobbi, Luca Tassoni, Elena Tinelli, Eleonora Scoccia, Sara Mrabet, Mario Orrico, Cecilia Righi, Carmen Maresca, Nicoletta D’Avino, Fabrizio Passamonti, Monica Giammarioli, Francesco Feliziani, Maria Serena Beato
TL;DR
This study updates the genetic diversity of SRLV in Italy, revealing region-specific clusters and suggesting the need for revised classification.
Contribution
The study provides new insights into the genetic diversity and regional distribution of SRLVs in Italy.
Findings
SRLVs show broad genetic diversity across Italy with some sub-genotypes restricted to specific regions.
Observed genetic clusters do not align with current sub-genotype classifications.
An updated classification system is suggested to better describe SRLV diversity.
Abstract
Small ruminant lentiviruses (SRLVs) are retroviruses infecting small ruminants, characterized by a high genetic variability. SRLVs infection may result in a variety of clinical signs in goats and sheep and is not species-specific. SRLVs are worldwide distributed with four distinct genotypes and numerous sub-genotypes described so far. Full understanding of SRLVs epidemiology is still a matter of research and genetic characterization remains a key tool for unrevealing the complexity of such infections. A previous study, exploring the genetic landscape of SRLV in Italy, reported considerable genetic heterogeneity across geographic regions and suggested the presence of new sub-genotypes. In light of these previous results, our study provides an update on the genetic characterization of SRLVs based on phylogenetic analysis of SRLVs positive samples collected during passive surveillance in…
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Taxonomy
TopicsHIV Research and Treatment · Poxvirus research and outbreaks · Herpesvirus Infections and Treatments