# The latest progression of N6-methyladenosine (m6A) RNA modification in diabetes mellitus and diabetic complications

## TL;DR

This review explores how N6-methyladenosine (m6A) RNA modification influences diabetes and its complications, highlighting recent findings and the need for further research.

## Contribution

The paper provides a comprehensive review of recent advances in m6A modification's role in diabetes mellitus and its complications.

## Key findings

- m6A modification is involved in regulating RNA metabolism and plays roles in diabetes and its complications.
- Expression patterns of m6A regulators vary across diabetes-related disorders and experimental models.
- The review emphasizes the need for further evaluation due to heterogeneity in study models and results.

## Abstract

The increasing global prevalence of diabetes mellitus and its complications continues to encourage exploration of novel molecular mechanisms for their prevention and treatment. N6-methyladenosine (m6A) is a methylation modification that occurs at the N6 position of adenosine in most RNAs and represents the most prevalent internal modification of eukaryotic messenger RNA. This dynamic and reversible modification is involved in regulating nearly all aspects of RNA metabolism and therefore plays important roles in various diseases, including diabetes mellitus and its complications. The present review summarizes recent advances in understanding the functions of m6A modification, its regulators, and potential downstream targets in diabetes mellitus and diabetic complications. Notably, different—and sometimes opposite—expression patterns and regulatory roles of m6A regulators have been reported within the same disease or among diabetes-related disorders. The heterogeneity of patient tissues, cell lines, and experimental models used across studies highlights the need for further comprehensive evaluation of the roles of m6A modification in diabetes mellitus and its complications. This review provides a valuable reference for tracking recent research progress in the field of m6A modification in diabetes mellitus.