# Ferroptosis: a new dawn in the treatment of acute lymphoblastic leukemia

**Authors:** Jiongping Han, Yifan Yang, Yuxin Wei, Jing Jin, Weiying Feng

PMC · DOI: 10.3389/fonc.2025.1669432 · Frontiers in Oncology · 2026-01-09

## TL;DR

This paper explores how triggering ferroptosis, a type of cell death, could offer new treatment strategies for acute lymphoblastic leukemia.

## Contribution

The paper systematically reviews ferroptosis mechanisms and their clinical potential in treating ALL.

## Key findings

- Ferroptosis plays a pivotal role in acute lymphoblastic leukemia.
- Targeting ferroptosis pathways could provide a novel therapeutic strategy for ALL.
- The review explores potential clinical applications for treatment and prognosis.

## Abstract

Acute lymphoblastic leukemia poses substantial challenges in therapeutic management. As a novel form of programmed cell death, ferroptosis has emerged as a promising research direction in cancer therapy. Studies have emphasized the pivotal role of ferroptosis in ALL, indicating that targeting this pathway could provide a novel therapeutic strategy. This article systematically reviews the molecular regulatory mechanisms of ferroptosis in ALL and explores its potential clinical applications in the treatment and prognostic evaluation of the disease.

## Linked entities

- **Diseases:** acute lymphoblastic leukemia (MONDO:0004967)

## Full-text entities

- **Diseases:** cancer (MESH:D009369), ALL (MESH:D054198)

## Full text

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## Figures

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## References

83 references — full list in the complete paper: https://tomesphere.com/paper/PMC12827144/full.md

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Source: https://tomesphere.com/paper/PMC12827144