# Exogenous insulin autoimmune syndrome: a case report and literature review

## TL;DR

This paper reports a rare case of insulin allergy in a diabetes patient and reviews related literature to improve diagnosis and treatment.

## Contribution

The paper presents a detailed case of EIAS in type 2 diabetes and enhances clinical understanding through analysis and literature review.

## Key findings

- EIAS can manifest with insulin resistance and allergic reactions.
- Limited awareness leads to frequent misdiagnosis of EIAS.
- Detailed case analysis aids in better clinical management of EIAS.

## Abstract

Exogenous Insulin Autoimmune Syndrome (EIAS) is a rare hypersensitivity reaction triggered by the administration of exogenous insulin. This reaction induces the production of insulin autoantibodies, leading to various clinical manifestations such as insulin resistance, hyperglycemia, recurrent hypoglycemic episodes, and allergic reactions. Due to limited clinical awareness, EIAS is often misdiagnosed or overlooked. Herein, we present a case of EIAS in a patient with type 2 diabetes mellitus, providing a detailed analysis of its clinical features, laboratory findings, differential diagnoses, therapeutic approaches, and clinical outcomes, supplemented by a literature review. This report aims to enhance clinicians’ diagnostic and therapeutic proficiency in managing this condition.