# Effect of end-effector robot training on lower limb motor function and balance in stroke patients: a systematic review and meta-analysis

**Authors:** Zejian Lou, Fuhai Wang, Difu Guan, Zhichuan Hu, Chen Wei, Xiaoquan Zhang

PMC · DOI: 10.3389/fneur.2025.1752104 · Frontiers in Neurology · 2026-01-09

## TL;DR

End-effector robot training may improve lower limb motor function and balance in stroke patients compared to conventional therapy, though effects on walking distance remain unclear.

## Contribution

A systematic review and meta-analysis of RCTs evaluating end-effector robot training's impact on stroke patients' motor and balance outcomes.

## Key findings

- End-effector robot training significantly improved lower limb motor function and balance in stroke patients.
- No significant difference was found in 6MWT distance between end-effector robot training and conventional therapy groups.
- Further research is needed to clarify long-term effects and mechanisms of end-effector robot training.

## Abstract

Evaluate the effect of end-effector robot training on lower limb motor function and balance in stroke patients.

Systematically reviewed the randomized controlled trials (RCTs) up to December 2025. Included studies compared end-effector robot training with conventional therapy for lower limb function and balance in stroke patients. Used PEDro scale and RevMan 5.4 software for meta-analysis.

Sixteen RCTs with 789 patients showed significant improvements in lower limb motor function (FAC score, FMA-L score, 10MWT speed) and balance function (BBS score) with end-effector robot training. No significant difference in 6MWT distance between groups.

End-effector robot training may enhance lower limb motor function and balance in stroke patients, but its effect on 6MWT distance is uncertain. Further research needed on training effectiveness and long-term mechanisms.

https://www.crd.york.ac.uk/PROSPERO/view/CRD420251009019, CRD420251009019.

## Linked entities

- **Diseases:** stroke (MONDO:0005098)

## Full-text entities

- **Diseases:** stroke (MESH:D020521)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

9 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12827104/full.md

## References

56 references — full list in the complete paper: https://tomesphere.com/paper/PMC12827104/full.md

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Source: https://tomesphere.com/paper/PMC12827104