# Initially Normal MRI, Delayed Splenial Lesion in Marchiafava‐Bignami Disease

## TL;DR

Marchiafava-Bignami disease can initially appear normal on MRI but later show brain lesions, highlighting the need for repeat imaging in at-risk patients.

## Contribution

Highlights the importance of repeat imaging for delayed diagnosis in Marchiafava-Bignami disease.

## Key findings

- Early MRI may show normal findings in Marchiafava-Bignami disease.
- Splenial lesions can develop later, necessitating repeat imaging in at-risk patients.

## Abstract

Marchiafava–Bignami disease (MBD) may show normal findings on early MRI. In patients with alcohol use disorder or risk of thiamine deficiency, repeat imaging is important because splenial lesions can develop later. Recognizing this pattern is key to avoiding delayed diagnosis.