# Impact of COVID-19 on new pharmacotherapy for insomnia: A matched cohort study using the national insurance claims database in Japan

## TL;DR

The study found that the COVID-19 pandemic led to a significant increase in new prescriptions for insomnia medications in Japan.

## Contribution

This study is the first to use a national insurance claims database to quantify the impact of COVID-19 on insomnia pharmacotherapy.

## Key findings

- Initiation of insomnia medications was 70% higher in the COVID-19 group compared to the control group.
- The increased risk was observed across all age groups, including those under 20 years old.
- Non-Benzodiazepines and short-acting Benzodiazepines showed the highest excess burden in prescriptions.

## Abstract

The COVID-19 pandemic has profoundly affected impacted both physical and mental well-being. This matched cohort study investigated the effects of COVID-19 on pharmacological treatments for insomnia, using Japan’s National Insurance Claims Database.

Data were matched by age, sex, Charlson Comorbidity Index (CCI) score, and enrollment month. Incidence rate ratios (IRR) and incidence rate differences (IRD) were calculated and compared for insomnia medication initiation, and subgroups based on age and sex categories. Sensitivity analyses were conducted for segmented intervals of 0–4, 5–12, and after 12 months.

The study included approximately 2 million pairs, predominantly women (59.4%), with a median follow-up of 7 months (Interquartile range, 4–12). Initiation of any insomnia medications occurred 77626 and 43142 times in the COVID-19 and control groups, respectively. IRR for new prescriptions was 1.7 times higher in the COVID-19 group (IRR: 1.71, 95% confidence interval [CI] 1.69–1.73), with an IRD of 1,634 events per 1,000,000 person-months (95%CI: 1599–1669). Non-Benzodiazepines and short-acting Benzodiazepines had the highest excess burdens among secondary endpoints. The risk was observed in all age categories, even in under 20 years (younger individuals: IRR: 1.46 95%CI 1.39–1.53, IRD: 380, 95%CI 333–427). Sensitivity analysis confirmed an increased risk over time, even after 12 months (IRD: 752, 95%CI 662–842).

COVID-19 significantly associates with an elevated risk of insomnia medication initiation, emphasizing the necessity for mental health support in post-COVID-19 care. This study offers insights into the pandemic’s influence on pharmacological treatment practices.