# What’s new on giant cell tumor of bone

## TL;DR

This paper reviews new treatments and techniques for giant cell tumor of bone, focusing on reducing recurrence and improving outcomes.

## Contribution

The paper highlights novel approaches like radiofrequency ablation and new filling materials to manage giant cell tumor of bone.

## Key findings

- Radiofrequency ablation alone shows favorable results for small, locally recurrent giant cell tumors of bone.
- New filling materials are being developed to prevent non-oncological complications like arthrosis and fractures.
- Serum tartrate-resistant acid phosphatase 5b measurement may help detect early local recurrence.

## Abstract

When treating extremities affected by giant cell tumor of bone (GCTB), curettage should be performed to preserve the joint as much as possible in order to obtain a good functional outcome. The local recurrence risk is high following curettage, but new techniques are being developed to reduce local recurrence. We present a review of the literature reporting favorable results of radiofrequency ablation alone in locally recurrent small GCTB. New filling materials are also being developed to prevent non-oncological complications such as arthrosis and fractures. Routine measurement of tartrate-resistant acid phosphatase 5b in serum may be helpful in detecting early instances of local recurrence. For unresectable or metastatic GCTB, there is an urgent need for a new drug that is as effective as denosumab, avoids side effects, and can be administered to pregnant women.