# Ampullaviruses: From Extreme Environments to Biotechnological Innovation

**Authors:** Alaa A. A. Aljabali, Mohamed El-Tanani, Almuthanna Alkaraki, Vijay Mishra, Yachana Mishra, Murtaza M. Tambuwala

PMC · DOI: 10.2174/0113892010325244240916112436 · 2024-09-27

## TL;DR

Ampullaviruses, found in extreme environments, have unique structures and properties that make them valuable for biotechnology and industrial applications.

## Contribution

This paper highlights the biotechnological potential of ampullaviruses and identifies key knowledge gaps for future research.

## Key findings

- Ampullaviruses have compact genomes and encode useful enzymes and proteins.
- They are being explored for enzyme stability, biosensors, and bioremediation.
- Their ecology and co-infection rates may lead to new viral vectors and phage therapy improvements.

## Abstract

Ampullaviruses are unique among viruses. They live in extreme environments and have special bottle-shaped architecture. These features make them useful tools for biotechnology. These viruses have compact genomes. They encode a range of enzymes and proteins. Their natural environment highlights their suitability for industrial applications. Ongoing research explores ways in which these viruses can improve enzyme stability. They are also employed in the creation of new biosensors and the development of new bioremediation techniques. High co-infection rates and the ecology of ampullaviruses at larger scales can also reveal new viral vectors. They can also help improve phage therapy. Here, we have explored the structure and function of ampullaviruses. We have focused on their use in biotechnology. We have also identified their characteristics that could prove to be useful. We have also pointed out key knowledge gaps and bridging them could further extend the biotechnological uses.

## Full-text entities

- **Diseases:** infectious diseases (MESH:D003141), cancer (MESH:D009369), bacterial infections (MESH:D001424), infection (MESH:D007239), ARSENAL (MESH:D020261)
- **Chemicals:** ABV (-)
- **Species:** Leptospira sp. AB (species) [taxon 103236], Bottigliavirus ABV3 (no rank) [taxon 2843874], Bacteria Latreille et al. 1825 (Bacteria stick insect, genus) [taxon 629395], Portogloboviridae (family) [taxon 2169572], Ampullaviridae (family) [taxon 573053], Homo sapiens (human, species) [taxon 9606], Cowpea mosaic virus (no rank) [taxon 12264], Ampullavirus [taxon 573054], Saccharomyces cerevisiae (baker's yeast, species) [taxon 4932], Viruses (acellular root) [taxon 10239], Mycosarcoma maydis (corn smut, species) [taxon 5270], Acidianus bottle-shaped virus (no rank) [taxon 437444], Human papillomavirus (species) [taxon 10566]

## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12824867/full.md

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Source: https://tomesphere.com/paper/PMC12824867