# Complications in a Patient With Multiple Myeloma Mimicking Bronchopneumonia

**Authors:** Aruna Gowda, Pranathi Guruswamy, Aadithya Shyllesh H, TC Nagesh Kumar

PMC · DOI: 10.7759/cureus.99897 · 2025-12-22

## TL;DR

A patient with multiple myeloma was initially misdiagnosed with pneumonia, highlighting the importance of considering underlying conditions in pulmonary complications.

## Contribution

This case emphasizes the need to recognize multiple myeloma as a potential cause of respiratory distress and altered mental status.

## Key findings

- The patient's respiratory distress was later attributed to multiple myeloma rather than pneumonia.
- Hypercalcemia and lytic bone lesions were key indicators of multiple myeloma.
- The patient's condition deteriorated despite treatment, leading to multi-organ dysfunction and death.

## Abstract

An elderly gentleman with a history of ischemic heart disease was admitted with respiratory distress. On evaluation, he exhibited renal dysfunction and elevated levels of total protein and globulin. The following day, the patient developed altered sensorium; further evaluation identified hypercalcemia, leading to a provisional diagnosis of hypercalcemic encephalopathy. A non-contrast CT scan of the brain revealed multiple lytic lesions in the skull, which were suspected to be a forerunning indicator for a possible multiple myeloma (MM). Bone marrow studies and protein electrophoresis further confirmed the same. A diagnosis of MM in the garb of an unsuspecting pneumonia was evident. Our patient was promptly initiated on chemotherapy alongside supportive therapy. However, he succumbed to illness following prolonged ICU admission, complicated by acute respiratory distress syndrome and multi-organ dysfunction. Hence, this case served as a reminder to consider the various agencies of pulmonary worsening in a patient with MM.

## Linked entities

- **Diseases:** ischemic heart disease (MONDO:0024644), hypercalcemia (MONDO:0001566), multiple myeloma (MONDO:0009693), acute respiratory distress syndrome (MONDO:0006502)

## Full-text entities

- **Diseases:** Bronchopneumonia (MESH:D001996), acute respiratory distress syndrome (MESH:D012128), ischemic heart disease (MESH:D017202), hypercalcemic encephalopathy (MESH:D001927), lytic lesions (MESH:D009059), renal dysfunction (MESH:D007674), pneumonia (MESH:D011014), hypercalcemia (MESH:D006934), multi-organ dysfunction (MESH:D009102), MM (MESH:D009101)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12824547/full.md

---
Source: https://tomesphere.com/paper/PMC12824547