# Biological Matrix‐Assisted Apexification: A Case Report Using PRF and MTA in Immature Necrotic Teeth

## TL;DR

This case report describes a new method using PRF and MTA to treat nonvital immature teeth by creating an apical barrier more effectively than traditional methods.

## Contribution

The novel use of PRF as a biological matrix combined with MTA for apexification in immature necrotic teeth is presented.

## Key findings

- PRF and MTA together provided a more predictable apical barrier formation.
- A multivisit approach was necessary due to persistent exudate for proper disinfection.
- The method showed potential for faster and more effective treatment outcomes.

## Abstract

It is challenging to treat an infected nonvital young permanent tooth endodontically because there is a lack of natural apical constriction. In order for the obturating material to be condensed, an apical barrier must be induced. Calcium hydroxide has historically been used to induce apexification. However, due to prolonged treatment time, multiple visits, and unpredictability in barrier formation, newer bioactive materials such as mineral trioxide aggregate (MTA) have been introduced for faster and more predictable outcomes. This case report presents the use of platelet‐rich fibrin (PRF) as a biological internal matrix in conjunction with MTA for apexification of immature necrotic teeth. Although a single‐visit procedure was initially planned, the presence of persistent exudate necessitated a multivisit approach to ensure thorough disinfection before final obturation.