Qinggan Mingshi Granules Inhibited Ferroptosis to Treat Diabetic Retinopathy in Mice Through NRF2/GPX4 Axis
Zhongyong Zhang, Qianqian Jin, Hongmin Zhao, Yingkai Liu, Meng Wang, Zhongqian Han, Jin Wu, Shuquan Lv, Xiaoyun Wang, Wei Chen, Qingjin Wang, Hailong Bai, Yuansong Wang
TL;DR
This study shows that Qinggan Mingshi Granules treat diabetic retinopathy in mice by reducing retinal damage through a specific biological pathway.
Contribution
The study reveals that Qinggan Mingshi Granules inhibit ferroptosis in diabetic retinopathy via the NRF2/GPX4 axis.
Findings
QGMS improved blood-retina barrier permeability and reduced retinal ferroptosis in diabetic mice.
QGMS increased the expression of NRF2/GPX4 axis proteins in the retina.
The effects of QGMS were blocked by an NRF2 inhibitor, confirming the pathway's role.
Abstract
Diabetic retinopathy (DR) is a common microvascular complication of diabetes, which seriously affected the life quality in diabetic patients. Developing novel therapy to improve DR is essential. Qinggan Mingshi granules (QGMS) have been demonstrated with protective effects on DR clinically. However, the mechanisms of QGMS remain unclear. In order to more thoroughly investigate the mechanism underlying the positive effects of QGMS on DR, a mouse model of DR was established in this study, and the positive effects of QGMS on the DR mice were observed. Next, the effects of QGMS on ferroptosis and the NRF2/GPX4 axis were investigated. In addition, we used an NRF2 inhibitor to determine whether QGMS inhibits ferroptosis in DR mice via the NRF2/GPX4 axis. Our results revealed the therapeutic effects of QGMS on DR including improving the permeability of blood–retina barrier (BRB), reducing…
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Taxonomy
TopicsFerroptosis and cancer prognosis · Endoplasmic Reticulum Stress and Disease · Clusterin in disease pathology