# The Inverted U: Exploring the Interconnectedness of Movement and Cognitive Function Across the Lifespan

**Authors:** Gerry Leisman, Rahela Alfasi, Oded Meiron, Amedeo D'Angiulli

PMC · DOI: 10.1002/wcs.70020 · 2026-01-21

## TL;DR

The paper explores how physical activity and cognitive function are linked across a lifetime, showing that moderate activity maximizes cognitive benefits.

## Contribution

The paper introduces the 'inverted U' model to explain how physical activity affects cognitive function optimally at moderate levels across the lifespan.

## Key findings

- Maternal physical activity positively influences fetal brain development.
- Moderate physical activity in adulthood preserves cognitive function and reduces neurodegenerative disease risk.
- Regular activity in older adults slows cognitive decline and improves quality of life.

## Abstract

The “inverted U” relationship between movement and cognition throughout the human lifespan highlights the intricate interplay between physical activity and cognitive function. This relationship posits that an optimal level of physical activity maximizes cognitive function, while insufficient activity can lead to suboptimal cognitive outcomes. This phenomenon is observed from fetal development to old age, emphasizing the importance of maintaining a balance in physical activity for overall well‐being. During fetal development, maternal physical activity positively influences fetal brain growth, laying the foundation for future cognitive and physical functioning. As the child develops, regular physical activity supports improvements in key cognitive functions such as attention, memory, and executive function abilities essential for learning and academic success. In adulthood, maintaining an active lifestyle continues to play a central role in preserving cognitive abilities and reducing the risk of neurodegenerative diseases such as Alzheimer's. The inverted U model suggests that optimal cognitive functioning is achieved at moderate levels of physical activity, while too little activity can be detrimental. In older adulthood, regular physical activity is vital for maintaining cognitive function, slowing cognitive decline, and improving quality of life. In summary, understanding the balance between physical activity and cognition across the lifespan is essential for promoting cognitive resilience and sustained well‐being.

This article is categorized under:
Cognitive Biology > Cognitive DevelopmentPsychology > Development and AgingPsychology > Learning

Cognitive Biology > Cognitive Development

Psychology > Development and Aging

Psychology > Learning

The inverted U in Movement and Cognition

## Full-text entities

- **Genes:** APOE (apolipoprotein E) [NCBI Gene 348] {aka AD2, APO-E, ApoE4, LDLCQ5, LPG}, APP (amyloid beta precursor protein) [NCBI Gene 351] {aka AAA, ABETA, ABPP, AD1, APPI, CTFgamma}, IGF1 (insulin like growth factor 1) [NCBI Gene 3479] {aka IGF, IGF-I, IGFI, MGF}, GH1 (growth hormone 1) [NCBI Gene 2688] {aka GH, GH-N, GHB5, GHN, IGHD1A, IGHD1B}
- **Diseases:** atrophy (MESH:D001284), startle (MESH:D016750), Reduced muscle mass (MESH:D009135), dementia (MESH:D003704), cognitive fatigue (MESH:D005221), Motor (MESH:D000068079), WMH (MESH:D056784), neurological impairments (MESH:D009422), demyelination (MESH:D003711), cognitive failure (MESH:D051437), reduced attention (MESH:D001523), brain degenerative pathologies (MESH:D019636), obesity (MESH:D009765), motor delays (MESH:D006968), frail (MESH:D000073496), decline (MESH:D060825), inflammation (MESH:D007249), brain deterioration (MESH:D001927), cardiovascular damage (MESH:D002318), cognition (MESH:D003072), neuropathological damage (MESH:D004194), EF (MESH:D003291), chronic diseases (MESH:D002908), impairments in attention, memory, (MESH:D008569), brain pathologies (MESH:D005598), Menopause (MESH:D008594), neurodevelopmental deficits (MESH:D009461), AD (MESH:D000544)
- **Chemicals:** iron (MESH:D007501), dopamine (MESH:D004298), progesterone (MESH:D011374), cholesterol (MESH:D002784), testosterone (MESH:D013739)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

14 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12824440/full.md

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Source: https://tomesphere.com/paper/PMC12824440