In Vivo Therapeutic Potential of Biologically Synthesized Nanoparticles From Pine Needle Leaf Extract in Streptozotocin‐Induced Diabetic Rats
Nourhane A. Darwich, Noura S. Abouzeinab, Ahmed F. El-Sayed, Rana El Hajj, Mahmoud I. Khalil
TL;DR
This study explores how nanoparticles made from pine needle extract can help treat diabetes in rats by reducing blood sugar and protecting kidney health.
Contribution
The novel contribution is the green synthesis and evaluation of GCY-AgNPs from pine needle extract for antidiabetic and kidney-protective effects in diabetic rats.
Findings
GCY-AgNPs showed the strongest protective effect against STZ-induced diabetic kidney damage.
Treatment with green-synthesized nanoparticles significantly reduced blood glucose and improved lipid profiles in diabetic rats.
In-silico studies confirmed strong interactions between nanoparticles and antidiabetic targets.
Abstract
Diabetes mellitus (DM) is one of the most widespread metabolic diseases characterized by increased blood glucose levels. According to the most recent research, the treatment of diabetes could be improved with the use of green‐synthesized nanoparticles due to their biocompatibility, efficient cellular uptake, and targeted therapy. In the present study, nanoparticles were biosynthesized using pine needle leaf extract to assess their antidiabetic potential in a streptozotocin (STZ)‐induced diabetic rat model. Initially, silver nanoparticles (AgNPs), yttrium‐doped AgNPs (Y‐AgNPs), and gadolinium–chromium–yttrium–doped AgNPs (GCY‐AgNPs) were green‐synthesized using pine needle leaf extract and characterized by UV‐Vis, PL, XRD, FTIR, SEM‐EDX, TEM, and VSM. Diabetes was induced in male Sprague–Dawley rats by a single intraperitoneal injection of STZ (55 mg/kg), followed by administration of…
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
Click any figure to enlarge with its caption.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
Figure 9
Figure 10
Figure 11
Figure 12
Figure 13
Figure 14
Figure 15
Figure 16
Figure 17
Figure 18
Figure 19
Figure 20
Figure 21
Figure 22
Figure 23
Figure 24
Figure 25
Figure 26Peer Reviews
No public reviews on file for this paper yet. If you reviewed it on a platform where reviews are public (OpenReview, ICLR, NeurIPS, ICML), you can paste yours below so the community can read it here.
Videos
No videos yet. Explain this paper in a talk, walkthrough, or lecture? Add one.
Taxonomy
TopicsNatural Antidiabetic Agents Studies · Nanoparticles: synthesis and applications · Graphene and Nanomaterials Applications