# Osimertinib inhibits the MYLK4-mediated phosphorylation of CDKAL1 to suppress stemness and chemoresistance in rhabdomyosarcoma

**Authors:** Takuto Itano, Rongsheng Huang, Toshifumi Ozaki, Eiji Nakata, Atsushi Fujimura

PMC · DOI: 10.1038/s41392-025-02548-6 · 2026-01-22

## Full-text entities

- **Genes:** EIF4G1 (eukaryotic translation initiation factor 4 gamma 1) [NCBI Gene 1981] {aka EIF-4G1, EIF4F, EIF4G, EIF4GI, P220, PARK18}, GAPDH (glyceraldehyde-3-phosphate dehydrogenase) [NCBI Gene 2597] {aka G3PD, GAPD, HEL-S-162eP}, MYC (MYC proto-oncogene, bHLH transcription factor) [NCBI Gene 4609] {aka MRTL, MYCC, bHLHe39, c-Myc}, PROM1 (prominin 1) [NCBI Gene 8842] {aka AC133, CD133, CORD12, MCDR2, MSTP061, PROML1}, SALL2 (spalt like transcription factor 2) [NCBI Gene 6297] {aka COLB, HSAL2, Sal-2, ZNF795, p150(Sal2)}, CDKAL1 (CDKAL1 threonylcarbamoyladenosine tRNA methylthiotransferase) [NCBI Gene 54901], EGFR (epidermal growth factor receptor) [NCBI Gene 1956] {aka ERBB, ERBB1, ERRP, HER1, NISBD2, NNCIS}, MYLK4 (myosin light chain kinase family member 4) [NCBI Gene 340156] {aka MLCK4, SgK085}
- **Diseases:** Cancer (MESH:D009369), soft-tissue sarcoma (MESH:D012509), RMS (MESH:D012208), AD-RD (MESH:D000544), metastasizes (MESH:D009362), RD (MESH:D000077733)
- **Chemicals:** acetyl-mask (-), Actinomycin D (MESH:D003609), Osimertinib (MESH:C000596361), threonine (MESH:D013912)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12824139/full.md

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Source: https://tomesphere.com/paper/PMC12824139