Advanced optical phantom mimicking microvascular and directed blood flow in mouse brain
Oleksii Sieryi, Anton Sdobnov, Igor Meglinski, Alexander Bykov
TL;DR
This paper introduces a new optical phantom that mimics blood flow in the mouse brain to improve neuroimaging and preclinical research.
Contribution
The novel multi-component dynamic optical phantom replicates cerebral hemodynamics with static and flowing blood-mimicking components.
Findings
The phantom's structure shows strong quantitative agreement with transcranial LSCI measurements of mouse brain hemodynamics.
Tissue-mimicking perfusion structures and optical attenuation properties significantly influence the blood flow index.
The phantom is a reproducible and physiologically relevant model for neuroimaging calibration and diagnostic validation.
Abstract
The accurate replication of cerebral hemodynamics is essential for advancing neuroimaging techniques and preclinical research. This study presents a novel multi-component dynamic optical phantom designed to model the complex blood flow dynamics of the mouse brain. The phantom incorporates a static base mimicking skull optical properties, a porous medium infused with a blood-mimicking solution to simulate microvascular perfusion, and a directed flow channel representing large vessels such as the sagittal sinus. The phantom structure was characterized using laser speckle contrast imaging (LSCI) to assess its ability to replicate in vivo-like blood flow patterns. The results demonstrate strong quantitative agreement between the phantom and transcranial LSCI measurements of mouse brain hemodynamics. Our key findings highlight the influence of tissue-mimicking perfusion structures and…
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Taxonomy
TopicsThermoregulation and physiological responses · Optical Imaging and Spectroscopy Techniques · Photoacoustic and Ultrasonic Imaging