Ginseng polysaccharides ameliorate DSS-induced inflammatory bowel disease by regulating gut microbiota in dogs

TL;DR

Ginseng polysaccharides help reduce inflammation and improve gut health in dogs with inflammatory bowel disease.

Contribution

This study shows ginseng polysaccharides can treat IBD in dogs by modulating gut microbiota and inflammation.

Findings

Ginseng polysaccharides reduced clinical symptoms and improved colonic histopathology in dogs with IBD.

Treatment increased gut microbiota diversity and enriched beneficial bacterial genera like Bacteroides and Megamonas.

The polysaccharides reversed suppressed carbohydrate metabolism pathways linked to DSS-induced IBD.

Abstract

Inflammatory bowel disease (IBD) is a common chronic gastrointestinal disorder in dogs that seriously affects health and quality of life. This study evaluated the effects of ginseng polysaccharides on dextran sodium sulfate (DSS)-induced IBD in dogs, with emphasis on clinical symptoms, serum parameters, and gut microbiota. Our findings revealed that treatment with ginseng polysaccharides alleviated clinical symptoms, improved colonic histopathology, and partially restored serum biochemical changes, including a significant reduction in C-reactive protein. Microbiota analysis showed increased alpha diversity and recovery of community composition, with enrichment of beneficial genera such as Bacteroides, Megamonas, and Fusobacterium, and reduction of Campylobacter. Functional prediction indicated that ginseng polysaccharides reversed DSS-associated suppression of carbohydrate metabolism pathways. These findings suggest that ginseng polysaccharides mitigate DSS-induced IBD in dogs by modulating inflammation and gut microbiota composition, supporting their potential as a natural therapeutic candidate for canine IBD.

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