# Predictors and oncological outcomes of achieving Pentafecta in radical cystectomy: a meta-analysis

## TL;DR

This study finds that achieving RC-Pentafecta after bladder cancer surgery is linked to better survival and identifies factors that predict success.

## Contribution

The study introduces RC-Pentafecta as a novel predictor of survival outcomes after radical cystectomy.

## Key findings

- Patients achieving RC-Pentafecta had significantly better overall and cancer-specific survival.
- Age, health status, and cancer stage are significant predictors of RC-Pentafecta achievement.
- Perioperative factors like hospital stay and comorbidities influence RC-Pentafecta outcomes.

## Abstract

This study aims to evaluate the predictive value of RC-Pentafecta on overall survival (OS) and cancer-specific survival (CSS) after radical cystectomy (RC) through meta-analysis and to explore the perioperative predictors of RC-Pentafecta.

This systematic review and meta-analysis were conducted in accordance with the PRISMA statement. We systematically searched PubMed, Embase, Cochrane Library, and Web of Science databases and included 9 retrospective studies from 2020 to 2025. The fixed effect model and random effect model were used for combined analysis.

The results of the study showed that patients who achieved RC-Pentafecta had significantly better OS and CSS than those who did not. In addition, Age, length of hospital stay (LOS), American Association of Medical Sciences Anesthesiology (ASA) score, diabetes mellitus, hypertension, Type of Urinary diversion (UD), pathological T-stage (pT), and pathological N-stage (pN) showed significant differences among the groups that achieved RC-Pentafecta.

RC-Pentafecta is a valuable criterion that can effectively predict OS and CSS in patients after RC. Age, perioperative health status, and pathological stage are important predictors of RC-Pentafecta.