# Dedifferentiated Liposarcoma With Low-Grade Osteosarcomatous Differentiation: A Rare Case With Long-Term Imaging Follow-Up

## TL;DR

A rare case of dedifferentiated liposarcoma with low-grade osteosarcomatous differentiation is reported, emphasizing the importance of imaging for diagnosis and monitoring.

## Contribution

This case highlights the diagnostic value of long-term imaging in identifying rare liposarcoma subtypes.

## Key findings

- Gradual enlargement of calcified components in lipomatous masses may indicate DDLPS with low-grade osteosarcomatous differentiation.
- Long-term imaging follow-up can aid in the preoperative diagnosis of this rare subtype of liposarcoma.

## Abstract

Dedifferentiated liposarcoma (DDLPS) with low-grade osteosarcomatous differentiation is extremely rare. However, this subtype is considered at a higher risk of early local recurrence than DDLPS without osteogenic differentiation, underscoring the importance of preoperative radiologic diagnosis. Here, we report a case of DDLPS with low-grade osteosarcomatous differentiation in an 80-year-old male located on the left dorsal thigh, in which long-term imaging follow-up was conducted prior to treatment. Gradual enlargement of calcified components in lipomatous masses may indicate the presence of DDLPS with low-grade osteosarcomatous differentiation.