# Analyses of the Effects of Wild‐Type TDP‐43 Overexpression in Oxytocin Neurons in Mice

## TL;DR

Overexpressing TDP-43 in oxytocin neurons reduces oxytocin cells but does not significantly affect behavior or metabolism in mice.

## Contribution

The study reveals the specific impact of TDP-43 overexpression on oxytocin neurons in the hypothalamus.

## Key findings

- TDP-43 overexpression decreases oxytocin-immunopositive cells in the hypothalamus.
- TDP-43 overexpression does not drive major behavioral or metabolic changes in mice.

## Abstract

Selective TDP‐43 overexpression in oxytocin neurons in the paraventricular nucleus of the hypothalamus causes a decrease in oxytocin‐immunopositive cells compared to uninjected mice.AAV‐mediated TDP‐43 overexpression in oxytocin neurons does not appear to be a major driver of behavioural and metabolic phenotypes in mice.

Selective TDP‐43 overexpression in oxytocin neurons in the paraventricular nucleus of the hypothalamus causes a decrease in oxytocin‐immunopositive cells compared to uninjected mice.

AAV‐mediated TDP‐43 overexpression in oxytocin neurons does not appear to be a major driver of behavioural and metabolic phenotypes in mice.