# Home-Based REM Sleep Without Atonia in Patients with Parkinson’s Disease: A Post Hoc Analysis of the ZEAL Study

## TL;DR

This study found that REM sleep duration is longer in Parkinson’s disease patients with REM sleep without atonia measured at home.

## Contribution

It is the first to associate RWA with REM sleep duration using home-based portable sleep monitoring in PD patients.

## Key findings

- REM sleep duration was significantly longer in patients with RWA compared to those without.
- RWA was not associated with other objective sleep metrics or clinical PD features.
- Adjustment for confounders confirmed the significant link between RWA and REM sleep duration.

## Abstract

REM sleep behavioral disorder (RBD) is of increasing interest in Parkinson’s disease (PD). Previous studies exploring the association between REM sleep without atonia (RWA) and clinical PD features or other objective sleep metrics are scarce and have used PSG findings. A mobile electroencephalography (EEG)/electrooculography (EOG) recording system with two channels can objectively measure sleep parameters, including RWA, during natural sleep at home. We investigated whether RWA measured on a portable recording device at home could be associated with clinical PD features or other sleep metrics using baseline data from the ZEAL study. Differences between patients with and without RWA was analyzed using ANCOVA test. REM sleep length was significantly longer in patients with RWA than in those without RWA. A multivariate comparison using ANCOVA showed a significant difference in log-transformed REM sleep duration of patients with RWA after adjustment for potential confounders (adjusted mean difference of 1.203; 95% confidence interval 0.468 to 1.937; p = 0.003). The strength of this study was that it evaluated the association between RWA during natural sleep at home and clinical variables as well as other sleep metrics. The major result was that patients with and without RWA did not differ in their clinical variables, and there was no relation between RWA and objective sleep metrics other than REM sleep. The duration of REM sleep may be associated with RWA during natural sleep at home.