# A Study Protocol for Developing a Pragmatic Aetiology-Based Silicosis Prevention and Elimination Approach in Southern Africa

**Authors:** Norman Nkuzi Khoza, Thokozani Patrick Mbonane, Phoka C. Rathebe, Masilu Daniel Masekameni

PMC · DOI: 10.3390/mps9010012 · Methods and Protocols · 2026-01-14

## TL;DR

This study aims to develop a practical approach to prevent silicosis in Southern Africa by evaluating dust control methods in mining, especially in small-scale operations.

## Contribution

The study introduces a novel method using portable tools and models to assess and control silica dust exposure in informal mining sectors.

## Key findings

- Portable FTIR and MPPD models will be used to evaluate dust control effectiveness in real-time.
- The approach reduces reliance on skilled personnel and analysis time for silica dust monitoring.
- The study will inform policy reforms to improve occupational health in artisanal mining.

## Abstract

Workers’ exposure to silica dust is a global occupational and public health concern and is particularly prevalent in Southern Africa, mainly because of inadequate dust control measures. It is worsened by the high prevalence of HIV/AIDS, which exacerbates tuberculosis and other occupational lung diseases. The prevalence of silicosis in the region ranges from 9 to 51%; however, silica dust exposure levels and controls, especially in the informal mining sector, particularly in artisanal small-scale mines (ASMs), leave much to be desired. This is important because silicosis is incurable and can only be eliminated by preventing worker exposure. Additionally, several studies have indicated inadequate occupational health and safety policies, weak inspection systems, inadequate monitoring and control technologies, and inadequate occupational health and hygiene skills. Furthermore, there is a near-absence of silica dust analysis laboratories in southern Africa, except in South Africa. This protocol aims to systematically evaluate the effectiveness of respirable dust and respirable crystalline silica dust exposure evaluation and control methodology for the mining industry. The study will entail testing the effectiveness of current dust control measures for controlling microscale particles using various exposure dose metrics, such as mass, number, and lung surface area concentrations. This will be achieved using a portable Fourier transform infrared spectroscope (FTIR) (Nanozen Industries Inc., Burnaby, BC, Canada), the Nanozen DustCount, which measures both the mass and particle size distribution. The surface area concentration will be analysed by inputting the particle size distribution (PSD) results into the Multiple-Path Particle Dosimetry Model (MPPD) to estimate the retained and cleared doses. The MPPD will help us understand the sub-micron dust deposition and the reduction rate using the controls. To the best of our knowledge, the proposed approach has never been used elsewhere or in our settings. The proposed approach will reduce dependence on highly skilled individuals, reduce the turnaround sampling and analysis time, and provide a reference for regional harmonised occupational exposure limit (OEL) guidelines as a guiding document on how to meet occupational health, safety and environment (OHSE) requirements in ASM settings. Therefore, the outcome of this study will influence policy reforms and protect hundreds of thousands of employees currently working without any form of exposure prevention or protection.

## Linked entities

- **Diseases:** silicosis (MONDO:0005960), tuberculosis (MONDO:0018076)

## Full-text entities

- **Diseases:** lung diseases (MESH:D008171), Silicosis (MESH:D012829), tuberculosis (MESH:D014376), HIV/AIDS (MESH:D015658)
- **Chemicals:** silica (MESH:D012822)

## Full text

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## Figures

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## References

45 references — full list in the complete paper: https://tomesphere.com/paper/PMC12821596/full.md

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Source: https://tomesphere.com/paper/PMC12821596