# Charting immune variation through genetics and single-cell genomics

## TL;DR

This study creates a detailed immune cell atlas of Chinese adults using multiomics data to better understand immune variation.

## Contribution

The study introduces a multiomics single-cell approach profiling immune cells in a diverse Chinese cohort, revealing new gene regulatory networks.

## Key findings

- The atlas identified 73 distinct immune cell subsets using RNA and chromatin accessibility data.
- It constructed gene regulatory networks linking enhancers to target genes in immune cells.
- The study uncovered hundreds of enhancer modules and novel regulators of immune cell identity.

## Abstract

Large-scale single-cell genomics projects have revolutionized our understanding of human immune variation. Yet most studies to date have been Eurocentric, limited in cell-type resolution, or restricted to a single data modality. The newly published Chinese Immune Multi-Omics Atlas helps address these gaps by profiling 428 healthy Chinese adults using a multiomics single-cell approach that combines single-cell RNA sequencing and single-cell chromatin accessibility sequencing across over 10 million immune cells. This integrated strategy enabled the identification of 73 distinct immune cell subsets and the construction of cell-type–specific gene regulatory networks linking noncoding enhancers to target genes. The atlas delineated hundreds of enhancer modules (eRegulons), highlighting both established and novel regulators of immune cell identity. By aligning transcriptomic and epigenomic maps, Yin et al. show how expanding both the ancestral diversity and data modalities of immune cell genomics can reveal new biology and provide a valuable addition to global reference cell atlases.