# Patient‐specific visco‐hyperelastic mechanical model for breast tumor localization in surgical planning

**Authors:** Felicia Alfano, Pedro Navas, Pablo Lamata, Karla Ferreres García, Juan E. Ortuño, Oscar Bueno Zamora, Santiago Lizarraga, Andrés Santos, Javier Pascau, José M. Goicolea, María J. Ledesma‐Carbayo

PMC · DOI: 10.1002/btm2.70044 · Bioengineering & Translational Medicine · 2025-07-09

## TL;DR

This paper introduces a patient-specific model to simulate breast tissue deformation, helping surgeons accurately locate tumors during surgery.

## Contribution

A novel visco-hyperelastic model using finite element analysis and tissue property optimization for tumor localization.

## Key findings

- The model achieved a tumor localization error of 8.12 ± 4.15 mm across 15 breast cancer cases.
- The approach provides more accurate deformation estimation compared to previous methods.

## Abstract

Breast‐conserving surgery is typically performed with the patient in a supine position, whereas preoperative diagnostic MRI breast images are obtained with the patient in a prone position. The change in patient positioning causes significant large deformations, requiring preoperative localization of the detected lesions. Developing an individual‐specific breast biomechanical model capable of simulating these deformations remains challenging yet highly desirable. This study presents a novel approach that combines finite element analysis with the optimization of mechanical properties of breast tissues, using only surface information to construct a personalized deformation model of the breast. A visco‐hyperelastic model is employed to characterize the stress–strain relationship of breast tissue. The proposed method has been tested on 15 cases of breast cancer and achieves a tumor localization error of 8.12 ± 4.15 mm. The results show that this approach provides an accurate and realistic estimation of large breast tissue deformations and yields smaller tumor localization errors compared to previously reported methods.

## Linked entities

- **Diseases:** breast cancer (MONDO:0004989)

## Full-text entities

- **Diseases:** deformations (MESH:D009140), tumor (MESH:D009369), breast cancer (MESH:D001943)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

6 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12821229/full.md

## References

57 references — full list in the complete paper: https://tomesphere.com/paper/PMC12821229/full.md

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Source: https://tomesphere.com/paper/PMC12821229