# Endoscopic Ultrasound‐Guided Tissue Acquisition for Diagnosing Hepatic Malignant Lymphoma

**Authors:** Yuichi Takano, Naoki Tamai, Jun Noda, Tetsushi Azami, Fumitaka Niiya, Masatsugu Nagahama

PMC · DOI: 10.1002/ccr3.71927 · Clinical Case Reports · 2026-01-21

## TL;DR

A 62-year-old man with liver masses was diagnosed with T-cell lymphoma using a safe endoscopic biopsy method, showing its potential as an alternative to traditional biopsies.

## Contribution

Demonstrates the safety and effectiveness of EUS-TA for diagnosing hepatic malignant lymphoma.

## Key findings

- EUS-TA using a 22-gauge needle diagnosed high-grade T-cell lymphoma without complications.
- EUS-TA is a viable alternative to percutaneous biopsy for liver lymphoma.
- Immunohistochemistry combined with EUS-TA aids in accurate diagnosis.

## Abstract

A 62‐year‐old man with right upper quadrant pain and fever was found to have numerous hepatic masses. Endoscopic ultrasound‐guided tissue acquisition (EUS‐TA) using a 22‐gauge fine‐needle biopsy enabled diagnosis of high‐grade T‐cell lymphoma without adverse events. This case underscores the potential of EUS‐TA as a safe and effective alternative to percutaneous biopsy for hepatic malignant lymphoma.

In recent years, the concept of “Endo‐Hepatology” has increased awareness of the clinical utility of EUS‐TA for liver diseases.Fine needle biopsy needles enable the diagnosis of hepatic malignant lymphoma in combination with immunohistochemistry.EUS‐TA may serve as an alternative to percutaneous biopsy in suspected cases.

In recent years, the concept of “Endo‐Hepatology” has increased awareness of the clinical utility of EUS‐TA for liver diseases.

Fine needle biopsy needles enable the diagnosis of hepatic malignant lymphoma in combination with immunohistochemistry.

EUS‐TA may serve as an alternative to percutaneous biopsy in suspected cases.

## Linked entities

- **Diseases:** T-cell lymphoma (MONDO:0015760)

## Full-text entities

- **Diseases:** hepatic masses (MESH:C536030), right (MESH:C535682), T-cell lymphoma (MESH:D016399), Hepatic Malignant Lymphoma (MESH:D008223), fever (MESH:D005334), pain (MESH:D010146)

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12820786/full.md

## References

3 references — full list in the complete paper: https://tomesphere.com/paper/PMC12820786/full.md

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Source: https://tomesphere.com/paper/PMC12820786