# Lysine demethylase 4A: from chromatin to centrosomes

## TL;DR

This paper shows that the enzyme KDM4A, known for regulating gene expression, also plays a role in centrosome stability, linking chromatin regulation to cell division.

## Contribution

The paper reveals a new localization and function of KDM4A at the centrosome, impacting mitosis and genome stability.

## Key findings

- KDM4A localizes to the pericentriolar material around the centrosome.
- Loss or inhibition of KDM4A causes centrosome amplification or fragmentation.
- KDM4A-dependent lysine methylation connects chromatin regulation to centrosome number control.

## Abstract

The lysine demethylase 4A (KDM4A) remodels chromatin by histone demethylation, regulating gene expression. In this issue, Chowdhury et al. report a previously undescribed localisation for KDM4A outside the nucleus, at the pericentriolar material around the centrosome. KDM4A interacts with centrosome proteins, and its loss or inhibition leads to centrosome amplification or fragmentation, which in turn perturbs mitosis and causes genome instability. These findings suggest a link between chromatin regulation and control of centrosome number, through the regulation of KDM4A‐dependent lysine methylation.

The lysine demethylase 4A (KDM4A) remodels chromatin by histone demethylation, regulating gene expression. In this issue, Chowdhury et al. report a previously undescribed localisation for KDM4A outside the nucleus, at the pericentriolar material around the centrosome. KDM4A interacts with centrosome proteins, and its loss or inhibition leads to centrosome amplification or fragmentation, which in turn perturbs mitosis and causes genome instability. These findings suggest a link between chromatin regulation and control of centrosome number through the regulation of KDM4A‐dependent lysine methylation.