# Blood Group Type and COVID-19 Severity at Tertiary Care Centre, Nepal: An Observational Study

**Authors:** Nabin Kumar Rauniyar, Late Shyam Pujari, Rojina Manandhar

PMC · DOI: 10.31729/jnma.9106 · JNMA: Journal of the Nepal Medical Association · 2025-07-01

## TL;DR

This study found that people with A positive blood group were more common among both mild and severe cases of COVID-19 in Nepal.

## Contribution

The study provides local evidence on the association between ABO blood types and COVID-19 severity in Nepal.

## Key findings

- A positive blood group was more prevalent in mild and severe COVID-19 cases.
- 31.45% of mild cases and 39.04% of severe cases had A positive blood group.
- Most patients were male and aged 21-40 years.

## Abstract

The respiratory infection with COVID-19 caused by the novel coronavirus SARS-CoV-2, emerged in December 2019 and was later declared a global pandemic by the world health organization. Clinical observations suggest the role of ABO blood types in susceptibility to COVID-19 infection. The study was designed to find the proportion of blood group distribution across the severity of COVID-19 patients.

This is an observational cross-section study conducted at a tertiary care hospital. All COVID-19 patient visiting hospital within January to December 2021 were included in the study. Their demographic profile, blood group and COVID-19 severity were recorded. Descriptive analysis of the date was done.

There were 399 confirmed case of COVID-19 during study period, out of which 278 (69.7%) were male and 198 (49.62%) were aged between 21-40 years. There were 78 (31.45%) amongst mild COVID-19 and 32 (39.04%) amongst severe COVID-19 (Bilateral Pneumonia) having A positive blood group.

The study suggests that patients with blood group A positive were more in the mild COVID-19, severe COVID-19 group.

## Linked entities

- **Diseases:** COVID-19 (MONDO:0100096)

## Full-text entities

- **Genes:** ABO (ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase) [NCBI Gene 28] {aka A3GALNT, A3GALT1, GTA, GTB, NAGAT}, ACE2 (angiotensin converting enzyme 2) [NCBI Gene 59272] {aka ACEH}
- **Diseases:** lung injury (MESH:D055370), diabetes (MESH:D003920), Respiratory complications (MESH:D012140), Lower Respiratory Tract Infection (MESH:D012141), inflammation (MESH:D007249), ARDS (MESH:D012128), Bilateral Pneumonia (MESH:D011014), COPD (MESH:D029424), COVID- (MESH:D000086382), hypertension (MESH:D006973), death (MESH:D003643)
- **Chemicals:** Oxygen (MESH:D010100)
- **Species:** Severe acute respiratory syndrome-related coronavirus (no rank) [taxon 694009], Severe acute respiratory syndrome coronavirus 2 (no rank) [taxon 2697049], Gammacoronavirus (genus) [taxon 694013], Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12820453/full.md

## References

20 references — full list in the complete paper: https://tomesphere.com/paper/PMC12820453/full.md

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Source: https://tomesphere.com/paper/PMC12820453