# Is Left Bundle Branch Pacing Feasible in Patients With Ventricular Septal Defect?

**Authors:** Binbin Luo, Longfu Jiang, Lu Zhang, Jiabo Shen

PMC · DOI: 10.1111/anec.70150 · Annals of Noninvasive Electrocardiology · 2026-01-20

## TL;DR

This paper explores whether left bundle branch pacing is safe and feasible in patients with a specific heart defect called perimembranous ventricular septal defect.

## Contribution

The study introduces a new method combining angiography and electroanatomic mapping to guide pacing lead placement in patients with pmVSD.

## Key findings

- Left bundle branch pacing was successfully implanted in two patients with pmVSD.
- The novel approach using angiography and electroanatomic mapping improved lead placement accuracy.
- The method reduced the risk of complications during the procedure.

## Abstract

His bundle typically passes through the central fibrous body of the atrioventricular node and then enters the membranous portion of the interventricular septum, where it branches into the left and right bundle branches. The feasibility and safety of left bundle branch area pacing (LBBAP) in patients with perimembranous ventricular septal defect (pmVSD) have not been reported.

This report presents two cases of left bundle branch pacing (LBBP) implantation in patients with perimembranous ventricular septal defect (pmVSD) and provides a novel approach to guide lead placement using both angiography and electroanatomic mapping, which ensures accuracy and reduces potential complications.

## Full-text entities

- **Diseases:** Ventricular Septal Defect (MESH:D006345)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12820410/full.md

## References

8 references — full list in the complete paper: https://tomesphere.com/paper/PMC12820410/full.md

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Source: https://tomesphere.com/paper/PMC12820410