# Insights into motor control: predict muscle activity from upper limb kinematics with LSTM networks

**Authors:** Marie D. Schmidt, Tobias Glasmachers, Ioannis Iossifidis

PMC · DOI: 10.1038/s41598-025-33696-y · Scientific Reports · 2026-01-05

## TL;DR

This study uses LSTM networks to predict muscle activity from upper limb movements, offering insights into motor control and potential applications in rehabilitation.

## Contribution

The study introduces an LSTM model that generalizes to unseen movements, capturing biomechanical principles rather than memorizing patterns.

## Key findings

- The LSTM model accurately predicts muscle activity for new repetitions of known movements.
- The model generalizes to unseen movements, indicating it captures underlying biomechanical principles.
- Training on diverse movement sets improves generalization compared to specialized training.

## Abstract

This study explores the relationship between upper limb kinematics and corresponding muscle activity, aiming to understand how predictive models can approximate motor control. We employ a Long Short-Term Memory (LSTM) network trained on kinematic end effector data to estimate muscle activity for eight muscles. The model exhibits strong predictive accuracy for new repetitions of known movements and generalizes to unseen movements, suggesting it captures underlying biomechanical principles rather than merely memorizing patterns. This generalization is particularly valuable for applications in rehabilitation and human-machine interaction, as it reduces the need for exhaustive datasets. To further investigate movement representation and learning, we analyze the impact of motion segmentation, hypothesizing that breaking movements into simpler components may improve model performance. Additionally, we explore the role of the swivel angle in reducing redundancy in arm kinematics. Another key focus is the effect of training data complexity on generalization. Specifically, we assess whether training on a diverse set of movements leads to better performance than specializing in either simple, single-joint movements or complex, multi-joint movements. The study is based on an experimental setup involving 23 distinct upper limb movements performed by five subjects. Our findings provide insights into the interplay between kinematics and muscle activity, contributing to motor control research and advancing neural network-based movement prediction.

## Full-text entities

- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12820307/full.md

## Figures

14 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12820307/full.md

## References

12 references — full list in the complete paper: https://tomesphere.com/paper/PMC12820307/full.md

---
Source: https://tomesphere.com/paper/PMC12820307