# Hepatic Teratoma: An Unusual Presentation of a Germ Cell Neoplasm

**Authors:** Muthu M Manickam, Ashwin Kumar, G Murugan

PMC · DOI: 10.7759/cureus.99796 · Cureus · 2025-12-21

## TL;DR

A rare case of a liver teratoma in a young woman is presented, highlighting its symptoms, imaging features, and successful surgical treatment.

## Contribution

This case report adds to the limited literature on primary hepatic teratoma and emphasizes its imaging and diagnostic features.

## Key findings

- Primary hepatic teratoma is a rare germ cell tumor with characteristic imaging features like fat and calcification.
- Surgical resection is curative for mature hepatic teratomas when diagnosed accurately.
- Radiological imaging is crucial for identifying and differentiating hepatic teratomas from other liver masses.

## Abstract

Primary hepatic teratoma is an exceptionally rare germ cell tumor. Its pathogenesis in the liver, an uncommon site for germ cell tumors, remains poorly understood. We present a case of a primary hepatic teratoma in a young adult female to highlight its clinical presentation, radiological hallmarks, and management. A 20-year-old female presented with a five-month history of dull, aching pain in the upper abdomen. Physical examination revealed a non-tender, palpable mass in the right hypochondrium. Routine blood investigations, including liver function tests and serum alpha-fetoprotein, were within normal limits. Contrast-enhanced computed tomography of the abdomen revealed a large, well-defined heterodense mass (~10.2 x 5.3 cm) in the liver. The mass exhibited characteristic heterogeneity with components of fat, calcification, and soft tissue, creating a mass effect on adjacent abdominal vessels. Based on the imaging findings, a provisional diagnosis of a complex benign tumor, likely a teratoma, was made. The patient underwent a successful surgical resection. Histopathological examination confirmed the presence of mature tissues derived from all three germ layers, leading to the definitive diagnosis of a mature cystic teratoma of the liver. This case underscores that primary hepatic teratoma, while exceedingly rare, should be considered in the differential diagnosis of a complex, heterogeneous liver mass, particularly in young patients. Cross-sectional imaging is pivotal in suggesting the diagnosis by identifying pathognomonic elements like fat and calcification. Complete surgical excision remains the cornerstone of treatment and is typically curative for mature lesions, emphasizing the importance of accurate radiological and histopathological correlation.

## Linked entities

- **Diseases:** germ cell tumor (MONDO:0003751)

## Full-text entities

- **Genes:** AFP (alpha fetoprotein) [NCBI Gene 174] {aka AFPD, FETA, HPAFP}
- **Diseases:** calcification (MESH:D002114), liver mass (MESH:D008107), pain (MESH:D010146), Hepatic Teratoma (MESH:D013724), germ cell tumor (MESH:D009373), benign tumor (MESH:D009369)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12819354/full.md

## References

12 references — full list in the complete paper: https://tomesphere.com/paper/PMC12819354/full.md

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Source: https://tomesphere.com/paper/PMC12819354