# Multidisciplinary management of surgery and postoperative recurrence in stage IV gallbladder cancer following conversion therapy: a case report

## TL;DR

A 61-year-old woman with stage IV gallbladder cancer was successfully treated with a combination of therapies, including surgery and immune checkpoint inhibitors, achieving 18 months of disease-free survival.

## Contribution

This case report highlights a successful multidisciplinary treatment approach for stage IV gallbladder cancer following conversion therapy.

## Key findings

- Triple-agent combination therapy led to a significant clinical response in the patient.
- Radical surgical resection was successfully performed after four months of conversion therapy.
- The patient remains disease-free at 18 months with maintenance therapy.

## Abstract

A 61-year-old female patient presented with a 10-day history of right upper abdominal pain and was subsequently diagnosed with stage IV gallbladder cancer based on preoperative imaging and pathological evaluation. Following multidisciplinary discussion, a triple-agent combination therapy was initiated. Although the patient developed severe grade II cutaneous toxicity during treatment, a significant clinical response was achieved, and symptoms were effectively relieved with supportive management. After four months of conversion therapy, the patient underwent successful radical surgical resection. Five months postoperatively, isolated hepatic metastases were identified, and a multidisciplinary team subsequently recommended radiofrequency ablation. The patient is currently receiving maintenance therapy with immune checkpoint inhibitors. At the most recent follow-up, the patient remains disease-free, with an overall survival of 18 months.