# Treatment challenges in glioblastoma: a case report

## TL;DR

This case report follows a glioblastoma patient's survival timeline and treatment journey, highlighting the use of liquid biopsies to track genetic changes.

## Contribution

The report demonstrates extended survival in a glioblastoma patient using aggressive treatment and liquid biopsy monitoring.

## Key findings

- The patient showed extended survival despite the aggressive nature of glioblastoma.
- Liquid biopsies effectively tracked dynamic alterations in cell-free DNA during treatment.
- Repeated radiochemotherapy was applied upon tumor recurrence.

## Abstract

This clinical case report aimed to show the survival timeline of a glioblastoma patient who underwent surgery and received adjuvant treatments in accordance with the Stupp protocol. Starting on the day of surgery, a liquid biopsy was employed to assess the dynamic alterations in cell-free DNA (cfDNA). Upon recurrence, reoperation was conducted, and repeated radiochemotherapy was applied. This clinical case is interesting due to the extended survival time, despite the extremely aggressive nature of the medical interventions. Liquid biopsies constitute a non-invasive method of characterising circulating tumour DNA (ctDNA) and evaluating genetic and epigenetic modifications, providing considerable potential for tumour diagnosis, prognosis, and management.