# Stc2a inhibits IGF-stimulated somatic growth in favor of organismal survival under hypoxic stress

## TL;DR

This study shows how a protein called Stc2a helps animals survive low-oxygen conditions by reducing growth and redirecting energy to essential functions.

## Contribution

The study identifies Stc2a as a novel factor that regulates the trade-off between growth and survival under hypoxia.

## Key findings

- Stc2a inhibits IGF signaling by blocking pappalysin metalloproteinases.
- Hypoxia-induced Stc2a expression is reduced in Hif2-deficient zebrafish.
- Stc2a deletion increases growth but reduces survival under hypoxia.

## Abstract

In response to hypoxia, animals reduce somatic growth to shift energy resources toward the maintenance of vital functions and organismal survival. Although this phenomenon is widespread, the systemic factors and mechanisms involved remain poorly understood. Here we report that hypoxia causes major changes in zebrafish transcriptomic landscapes with hormonal activity or hormonal signaling identified as most prominently up-regulated GO term and KEGG pathway. Among the top in this group is Stanniocalcin 2a (Stc2a), a secreted glycoprotein that inhibits insulin-like growth factor (IGF) signaling by binding to pappalysin metalloproteinases and inhibiting their activities. The hypoxic induction of stc2a expression is attenuated in Hif2-deficient fish. Genetic deletion of Stc2a increased the developmental speed and growth rate, resulting in enlarged adult organ and body size. Under hypoxia, stc2a-/- fish grew faster than wild-type fish but showed reduced survival rate. These phenotypes were reversed by inhibiting pappalysin metalloproteinase activity and by blocking IGF signaling. These findings suggest that Stc2a limits IGF-mediated somatic growth in favor of survival and that the induction of Stc2a is part of a conserved mechanism regulating the trade-off between somatic growth and organismal survival under hypoxic stress.