# Damage‐associated molecular patterns and coagulation

## TL;DR

This paper explores how DAMPs, released during tissue injury, promote clotting and inflammation, suggesting new ways to diagnose and treat thromboinflammatory diseases.

## Contribution

The paper highlights DAMPs as key players in linking coagulation and immunity, offering novel therapeutic and diagnostic opportunities.

## Key findings

- DAMPs activate coagulation, inflammation, and immune pathways to promote clot formation.
- DAMPs drive immunothrombosis, a cycle seen in critical illnesses.
- Targeting DAMPs could lead to new treatments for thromboinflammatory diseases.

## Abstract

Damage‐associated molecular patterns (DAMPs), released into the extracellular space following tissue injury, are increasingly recognised as potent procoagulant molecules integral to haemostasis and the pathogenesis of thrombosis. Their procoagulant influence spans all phases of the cell‐based model of coagulation while simultaneously extending beyond traditional haemostatic pathways through direct modulation of inflammatory and innate immune responses. By coupling coagulation and immunity, DAMPs drive the self‐perpetuating cycle of immunothrombosis characteristic of many critical illnesses. Targeting this underexplored interface offers the promise of novel diagnostic and therapeutic approaches, particularly in conditions where coagulopathy coexists with hyperinflammatory states.

Injured cells release damage‐associated molecular patterns (DAMPs), which promote clot formation by activating coagulation, inflammation and immune pathways. Targeting these immunothrombotic mechanisms, via DAMPs, offers new opportunities for diagnosis and therapy in thromboinflammatory disease.