# Intrahepatic Cholangiocarcinoma With Rare Metastasis Locations in a Younger Patient: A Case Report

**Authors:** Inês P Carvalho, Adalmira Gomes, Bárbara Pena, Inês Bonito, Célia Carmo

PMC · DOI: 10.7759/cureus.99787 · Cureus · 2025-12-21

## TL;DR

A 41-year-old woman was diagnosed with aggressive intrahepatic cholangiocarcinoma that spread to unusual locations, highlighting the need for awareness of atypical symptoms in younger patients.

## Contribution

Reports a rare case of intrahepatic cholangiocarcinoma with unusual metastasis locations in a younger patient.

## Key findings

- The patient had metastases in the liver, bone, lung, clivus, spleen, and soft tissue.
- Intrahepatic cholangiocarcinoma was confirmed as the primary tumor via biopsy.
- The case suggests a potential rise in incidence among younger age groups with worse outcomes.

## Abstract

Intrahepatic cholangiocarcinoma is a highly aggressive tumor, usually diagnosed in late middle age and often at an advanced stage. In this clinical case, we report the case of a 41-year-old woman presenting with diplopia, blurred vision, and headache for three days. Imaging investigations showed metastases in the liver, bone, lung, clivus, and rare locations for this type of cancer, such as the spleen and a soft tissue lesion with pre-protuberance expression. The biopsy of the liver lesions confirmed intrahepatic cholangiocarcinoma as the primary tumor. Awareness should be raised regarding the possible atypical symptoms of this cancer and the potential increase in incidence among younger age groups, which may be associated with worse outcomes.

## Linked entities

- **Diseases:** intrahepatic cholangiocarcinoma (MONDO:0003210)

## Full-text entities

- **Diseases:** cancer (MESH:D009369), blurred vision (MESH:D014786), diplopia (MESH:D004172), headache (MESH:D006261), Metastasis (MESH:D009362), Intrahepatic Cholangiocarcinoma (MESH:D018281), liver lesions (MESH:D008107)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12819010/full.md

## References

16 references — full list in the complete paper: https://tomesphere.com/paper/PMC12819010/full.md

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Source: https://tomesphere.com/paper/PMC12819010