# A case of necrotizing pneumonia leading to respiratory failure and tracheostomy

**Authors:** Nurul 'Aifaa Mohd Azmi, Shao Keong Koeh, Tuan Sharifah Syuwaibah Tuan Zainal, Mohd Zulfakar Mazlan

PMC · DOI: 10.1016/j.idcr.2025.e02480 · IDCases · 2026-01-06

## TL;DR

A 58-year-old woman with necrotizing pneumonia required tracheostomy and intensive care, highlighting the disease's severity and lack of targeted treatments.

## Contribution

This case report highlights the challenges in managing necrotizing pneumonia and emphasizes the need for supportive care in critical cases.

## Key findings

- Necrotizing pneumonia can lead to respiratory failure requiring tracheostomy.
- Treatment with carbapenem, oxazolidinone, and corticosteroid led to recovery.
- Current management focuses on supportive care due to lack of specific anti-inflammatory treatments.

## Abstract

Necrotizing pneumonia is a severe lung infection characterized by pulmonary necrosis and high mortality rates of up to 50 %. It is typically caused by toxin-producing pathogens, such as Staphylococcus aureus and Klebsiella pneumoniae. Limited guidelines exist for its management, making its treatment challenging. Case report: We discuss a case of a 58-year-old Malay woman with no significant comorbidity but developed necrotizing pneumonia. The diagnosis was confirmed using computed tomography (CT) of the thorax. Treatment with carbapenem, oxazolidinone and corticosteroid led to significant recovery. Conclusion: To date, no specific anti-inflammatory treatments exist for severe necrotizing pneumonia. Since systemic inflammation and multi-organ failure drive mortality, management focuses on supportive care aimed at maintaining oxygenation and hemodynamic stability to improve outcomes in critically ill patients.

## Linked entities

- **Chemicals:** carbapenem (PubChem CID 441133), oxazolidinone (PubChem CID 73949)
- **Diseases:** respiratory failure (MONDO:0021113)

## Full-text entities

- **Diseases:** inflammation (MESH:D007249), Necrotizing pneumonia (MESH:D000071067), pulmonary necrosis (MESH:D009336), lung infection (MESH:D012141), critically ill (MESH:D016638), multi-organ failure (MESH:D009102), respiratory failure (MESH:D012131)
- **Chemicals:** carbapenem (MESH:D015780), oxazolidinone (MESH:D023303)
- **Species:** Klebsiella pneumoniae (species) [taxon 573], Homo sapiens (human, species) [taxon 9606], Staphylococcus aureus (species) [taxon 1280]

## Full text

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## Figures

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## References

21 references — full list in the complete paper: https://tomesphere.com/paper/PMC12818986/full.md

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Source: https://tomesphere.com/paper/PMC12818986