# Extensive Lymphadenopathy in an HIV‐Negative Patient With Multidrug‐Resistant Tuberculosis

**Authors:** Tomoyuki Araya, Toshiyuki Kita, Kazuhiko Iwasaki, Takayuki Higashi, Ryo Hara, Hazuki Takato

PMC · DOI: 10.1002/rcr2.70480 · Respirology Case Reports · 2026-01-20

## TL;DR

An HIV-negative patient with drug-resistant tuberculosis developed severe lymph node swelling, showing that this can happen even without HIV.

## Contribution

Demonstrates that extensive lymphadenopathy can occur in HIV-negative patients with multidrug-resistant tuberculosis.

## Key findings

- An HIV-negative patient with multidrug-resistant tuberculosis had severe lymph node involvement.
- Extensive lymphadenopathy was observed in multiple extrapulmonary regions.
- This case shows that marked lymph node disease can occur in HIV-negative individuals with TB.

## Abstract

Tuberculous lymphadenitis is generally more severe in patients with HIV infection. We present an HIV‐negative patient with multidrug‐resistant tuberculosis who developed severe, extensive lymphadenitis involving multiple extrapulmonary regions. This clinical image highlights that marked lymph node involvement may occur in HIV‐negative patients presenting with pronounced systemic symptoms.

Extensive lymphadenopathy is uncommon in HIV‐negative patients with tuberculosis. This clinical image highlights the striking CT appearance of extensive extrapulmonary lymph node involvement in symptomatic multidrug‐resistant tuberculosis, even in the absence of HIV infection.

## Linked entities

- **Diseases:** tuberculosis (MONDO:0018076), multidrug-resistant tuberculosis (MONDO:0005861), lymphadenitis (MONDO:0002052)

## Full-text entities

- **Diseases:** lymph node involvement (MESH:D000072717), Tuberculous lymphadenitis (MESH:D014388), Lymphadenopathy (MESH:D008206), multidrug- (MESH:D018088), lymphadenitis (MESH:D008199), Tuberculosis (MESH:D014376), HIV infection (MESH:D015658)
- **Species:** Homo sapiens (human, species) [taxon 9606], Human immunodeficiency virus 1 (no rank) [taxon 11676]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12818960/full.md

## References

2 references — full list in the complete paper: https://tomesphere.com/paper/PMC12818960/full.md

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Source: https://tomesphere.com/paper/PMC12818960