# Efficiency of Sorting Site of Care for Frail Patients Undergoing Mastectomy

**Authors:** Claire R. Morton, Yu-Jen Chen, Kenneth Williams, Randall A. Bloch, Ezra S. Brooks, Christina Minami, Louis L. Nguyen

PMC · DOI: 10.1245/s10434-025-18910-5 · Annals of surgical oncology · 2026-01-14

## TL;DR

Frail patients undergoing mastectomy may benefit economically from outpatient care despite slightly higher transfer risks.

## Contribution

This study quantifies the economic benefits of outpatient mastectomy for frail patients and evaluates transfer risks.

## Key findings

- Frailty is associated with increased odds of inpatient care (OR, 5.856; p < 0.001).
- Prefrail or frail patients in ASCs have a 0.4% transfer rate, with cost savings of $8404 per patient.
- Transfer rates would need to increase over 100-fold to negate cost savings from ambulatory procedures.

## Abstract

Patients undergo mastectomy in both ambulatory surgery centers (ASCs) and inpatient settings. Guidelines for site selection are poorly defined. Older adults, particularly those with frailty, are at increased risk of adverse outcomes postoperatively. Transfer to an acute hospital is a unique adverse event suggesting potentially inappropriate ASC care.

The authors used logistic regression modeling to describe the association of frailty with site of care and transfer, and modeled expected costs associated with ambulatory mastectomy for robust and prefrail or frail patients.

In ASCs, 85.3% of all patients and 51.3% of prefrail or frail patients underwent mastectomy. Frailty or prefrailty was associated with increased odds of inpatient care (odds ratio [OR], 5.856; p < 0.001). Odds of transfer were higher among prefrail and frail patients (OR, 2.640; p < 0.05), but rates remained low (< 0.4%). Rates of transfer needed to negate cost-savings from ambulatory procedures are more than 100 times the current rate (38%; standard error, 4.7%). If all prefrail and frail patients received care at ASCs, expected cost savings would be $8404 per patient.

Despite slightly higher rates of transfer, clinicians should consider treating frail and prefrail older adults in ASCs given possible economic benefits.

## Full-text entities

- **Diseases:** ASC (MESH:D065309), Frailty (MESH:D000073496), Mastectomy (MESH:D000072656)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

30 references — full list in the complete paper: https://tomesphere.com/paper/PMC12818549/full.md

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Source: https://tomesphere.com/paper/PMC12818549