# Multiple Orthokeratinized Odontogenic Cysts in a Female Adolescent Patient: A Report of a Rare Case

**Authors:** Kanimozhiy Senguttuvan, Senthil Kumar, Satish Kumar

PMC · DOI: 10.7759/cureus.99771 · Cureus · 2025-12-21

## TL;DR

This paper reports a rare case of multiple orthokeratinized odontogenic cysts in a young female patient and discusses their clinical and diagnostic features.

## Contribution

The novelty lies in documenting a rare case of multiple OOCs in a single patient and emphasizing their distinct characteristics.

## Key findings

- Multiple orthokeratinized odontogenic cysts were identified in a 17-year-old female patient.
- Histopathological analysis confirmed the diagnosis and highlighted the cysts' distinct biological behavior.
- The case underscores the rarity and unique clinical presentation of multiple OOCs.

## Abstract

An orthokeratinized odontogenic cyst (OOC) is a rare developmental odontogenic cyst characterized by orthokeratinized stratified squamous epithelium. It was previously considered a variant of an odontogenic keratocyst (OKC) but has since been classified as a separate entity due to differing biological behavior. We present a case of an OOC in a 17-year-old female patient with extra-oral swelling on her right ramus region. Radiolucency in both the jaws was discovered incidentally on routine OPG examination. These lesions were surgically enucleated, and histopathological examination confirmed the diagnosis. This report highlights the clinical, radiographic, and histological characteristics of OOCs with their rarity of multiple incidence and reviews pertinent literature.

## Linked entities

- **Diseases:** odontogenic keratocyst (MONDO:0018648)

## Full-text entities

- **Genes:** BTF3P11 (basic transcription factor 3 pseudogene 11) [NCBI Gene 690] {aka BRF3L1, BTF3L1, HUMBTFB, OCIF, OPG, TNFRSF11B}
- **Diseases:** OKC (MESH:D009807), swelling (MESH:D004487)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12818339/full.md

## References

9 references — full list in the complete paper: https://tomesphere.com/paper/PMC12818339/full.md

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Source: https://tomesphere.com/paper/PMC12818339