# Association of TRPV1 genetic variants with cognitive functions in Parkinson disease

## TL;DR

This study explores how genetic variations in TRPV1 are linked to cognitive functions in Parkinson's disease patients and healthy controls.

## Contribution

The study identifies specific TRPV1 genetic variants that influence cognitive performance in Parkinson's disease.

## Key findings

- TRPV1 rs12936340 is associated with visuospatial function and MoCA naming.
- TRPV1 rs182637 is associated with MoCA total score and attention.
- PD diagnosis moderates the effects of TRPV1 variants on cognitive domains.

## Abstract

Parkinson disease (PD) is a neurodegenerative disorder characterized by motor and non-motor symptoms, including cognitive impairment. The transient receptor potential vanilloid 1 (TRPV1) channel has been implicated in neurodegenerative processes, but its contribution to cognitive variation in PD remains unclear. This study aimed to determine whether TRPV1 genetic variants influence cognitive performance and whether these effects are moderated by PD status. Three TRPV1 polymorphisms (rs8065080, rs12936340, rs182637) were genotyped in 274 healthy control subjects and 127 individuals with PD. Cognitive function was assessed across global, executive, visuospatial, memory, attention, and language domains. Moderation analysis revealed that rs12936340 and rs182637 were associated with cognitive performance, and PD status moderated these associations in specific domains. These findings suggest that TRPV1 variation relates to cognitive outcomes in PD and may contribute to individual differences in vulnerability to PD-related cognitive impairment.

•401 participants (274 control subjects, 127 PD) underwent TRPV1 genotyping and cognition tests•TRPV1 rs12936340 is associated with visuospatial function and MoCA naming•TRPV1 rs182637 is associated with MoCA total score and MoCA attention•PD diagnosis moderated rs12936340-naming and rs182637-attention effects

401 participants (274 control subjects, 127 PD) underwent TRPV1 genotyping and cognition tests

TRPV1 rs12936340 is associated with visuospatial function and MoCA naming

TRPV1 rs182637 is associated with MoCA total score and MoCA attention

PD diagnosis moderated rs12936340-naming and rs182637-attention effects

Health sciences; Medicine; Clinical genetics; Neurology; Human genetics