# Urinary Neutrophil Mediators as Predictive Biomarkers for Severe Dengue in Adults

## TL;DR

This study identifies two urinary biomarkers that can predict severe dengue in adults during the early febrile phase.

## Contribution

The study introduces noninvasive urinary biomarkers for early prediction of severe dengue.

## Key findings

- Urinary NGAL and suPAR showed strong predictive power with AUCs of 0.88 and 0.79, respectively.
- Noninvasive sampling provides a practical tool for risk stratification in dengue patients.

## Abstract

Reliable prognostic biomarkers remain an unmet need in dengue. We evaluated urinary neutrophil gelatinase-associated lipocalin and soluble urokinase plasminogen activator receptor for severe dengue prediction in the febrile phase. Urinary neutrophil gelatinase-associated lipocalin and soluble urokinase plasminogen activator receptor demonstrated areas under the receiver operating curve of 0.88 and 0.79, respectively, in discriminating against severe dengue. The noninvasive sampling offers practical advantages as risk stratification tools.