# First person – Priyanka Tibarewal

## TL;DR

This paper explores the role of impaired nuclear PTEN function in causing macrocephaly, lymphadenopathy, and late-onset cancer in PTEN hamartoma tumour syndrome.

## Contribution

The study identifies impaired nuclear PTEN function as a novel driver of disease manifestations in PTEN hamartoma tumour syndrome.

## Key findings

- Impaired nuclear PTEN function leads to macrocephaly and lymphadenopathy in PTEN hamartoma tumour syndrome.
- The study links PTEN dysfunction to late-onset cancer development in the syndrome.
- Research focuses on disease mechanisms and drug repurposing for PHTS.

## Abstract

First Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping researchers promote themselves alongside their papers. Priyanka Tibarewal is first author on ‘
Impaired nuclear PTEN function drives macrocephaly, lymphadenopathy and late-onset cancer in PTEN hamartoma tumour syndrome’, published in DMM. Priyanka is a senior research associate in the lab of Bart Vanhaesebroeck at University College London, London, UK, investigating the disease mechanism and repurposing drugs for PTEN hamartoma tumour syndrome (PHTS).